生物技术系-孙虎男

发布者：白巍发布时间：2019-11-15浏览次数：2279

孙虎男（1978.01-），男，副教授/博士，博士后，硕士生（学硕、专硕）导师。2008年于韩国忠南大学获兽医机能学博士学位。近5年，主持和参与省自然基金项目3项，厅局级项目1项，主持校级三纵三横项目1项，教改项目1项，发表教研论文1篇，获得国家发明专利2项，指导国家级大创项目1项、研创项目1项，撰写专著1篇，获得黑龙江省农垦总局科技进步二等奖1项，发表论文25篇，其中SCI 24篇，第一（共同第一）7篇，通讯（共同通讯）18篇。主要承担本科《细胞生物学》、《细胞生物学实验》和研究生《细胞信号传导》等课程的教学任务。目前主要研究方向为：抗癌药物筛选、过氧化物酶功能研究、低温等离子体生物学效应。

◆ 教研成果（项目名称，来源，时间，位次等。）

（1）项目及获奖

校级教改课题，大数据背景下的细胞生物学实验课程数字资源库的建设研究（NDJY2240），2022.11-2024.11，主持人。

（2）论文及教材

孙虎男，韩英浩。《高校细胞生物学实验课程数字资源库建设探究》，安徽农学通报，2024年03期。

（3）指导学生“双创”情况

肖婉秋、张惠娜、苏婷.国家级大学生创新创业训练计划项目，Prx V对苦木提取物诱导宫颈癌SiHa细胞凋亡的调控作用及其机制研究，202210223020，黑龙江省教育厅，2022.06-2023.06 在研。

郝莹莹. 黑龙江八一农垦大学研究生创新科研项目，P e r o x i r e d o x i n I 在氧化应激下对肝癌细胞干性的调控作用及分子机制研究，Y J S C X 2 0 2 3 - Y 6 6，2023.12-2024.12，在研。

◆ 科研成果：

（1）项目及获奖

黑龙江省自然科学基金联合培育项目、博来霉素诱导肺纤维化过程中Prx I的调控作用机制，2022.09-2025.09，10万，在研，主持人。

黑龙江省农垦总局科技进步奖，Prx I对LPS诱导小鼠死亡的保护作用及其机理研究，二等奖，2020.09，第一完成人。

（2）论文及专著

1. 第一作者论文

（1）Hu-Nan Sun, Chen-Xi Ren, Dong Hun Lee, Wei-Hao Wang, Xiao-Yu Guo, Ying-Ying Hao, Xiao-Ming Wang, Hui-Na Zhang , Wan-Qiu Xiao, Nan Li, Jie Cong, Ying-Hao Han and Taeho Kwon. PRDX1 Negatively Regulates Bleomycin-Diduced Pulmonary Fibrosis via Inhibiting the Epithelial-Mesenchymal Transition and Lung Fibroblast Proliferation in vitro and in vivo. Cellular & Molecular Biology Letters 2023(28):48 (IF=8.3, 1区, Top) .

（2）Sun HN, Guo XY, Xie DP, Wang XM, Ren CX, Han YH, Yu NN, Huang YL, Kwon T. Knockdown of Peroxiredoxin V increased the cytotoxicity of non-thermal plasma-treated culture medium to A549 cells. Aging (Albany NY) 2022 May 11;14(9):4000-4013. (IF=5.955, 2区)

（3）Sun HN, Xie DP, Ren CX, Guo XY, Zhang HN, Xiao WQ, Han YH, Cui YD, Kwon T. Ethyl β-Carboline-3-Carboxylate Increases Cervical Cancer Cell Apoptosis Through ROS-p38 MAPK Signaling Pathway. In Vivo 2022 May-Jun;36(3):1178-1187. (IF=2.4, 4区)

（4）HU-NAN SUN, CHEN-XI REN, YI-XI GONG1, DAN-PING XIE and TAEHO KWON. Regulatory function of peroxiredoxin I on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung cancer development. Oncology Letter 2021 Jun;21(6):465. (IF=2.3，4区) Review

（5）Chandimali N, Sun HN(co-first), Park YH, Kwon T. BRM270 Suppresses Cervical Cancer Stem Cell Characteristics and Progression by Inhibiting SOX2. In Vivo. 2020 May-Jun;34(3):1085-1094. （IF=1.6，4区）

（6）Koh H, Sun HN (co-first), Xing Z, Liu R, Chandimali N, Kwon T, Lee DS. Wogonin Influences Osteosarcoma Stem Cell Stemness Through ROS-dependent Signaling. In Vivo. 2020 May-Jun;34(3):1077-1084. （IF=1.6，4区）

（7）Zhen X, Sun HN(co-first), Liu R, Choi HS, Lee DS. Non-thermal plasma-activated Medium Induces Apoptosis of Aspc1 Cells Through the ROS-dependent Autophagy Pathway. In Vivo. 2020 Jan-Feb;34(1):143-153. （IF=1.6，4区）

2. 通讯作者论文（与第一作者论文无重复）

（8）Zhang HN, Xiao WQ, Lee DH, Li N, Feng YY, Su T, Gu HY, Yoon I, Jung H, Lee KH, Cho HJ, Han YH, Sun HN*(co-correspondence), Kwon T. Cisplatin Induces Kidney Cell Death via ROS-dependent MAPK Signaling Pathways by Targeting Peroxiredoxin I and II in African Green Monkey (Chlorocebus aethiops sabaeus) Kidney Cells. In Vivo. 2024 Mar-Apr;38(2):630-639. (IF=2.3, 4区）

（9）Han YH, Mao YY, Lee KH, Cho HJ, Yu NN, Xing XY, Wang AG, Jin MH, Hong KS, Sun HN*(co-correspondence), Kwon T. Peroxiredoxin II regulates exosome secretion from dermal mesenchymal stem cells through the ISGylation signaling pathway. Cell Commun Signal. 2023 Oct 20;21(1):296. (IF=8.4, 2区）

（10）Han YH, Wang Y, Lee SJ, Jin MH, Sun HN*(co-correspondence), Kwon T.Regulation of anoikis by extrinsic death receptor pathways. Cell Commun Signal. 2023 Sep 4;21(1):227. (IF=8.4, 2区）

（11）Han YH, Feng L, Lee SJ, Zhang YQ, Wang AG, Jin MH, Sun HN*(co-correspondence), Kwon T*. Depletion of peroxiredoxin II promotes keratinocyte apoptosis and alleviates psoriatic skin lesions via the PI3K/AKT/GSK3β signaling axis. Cell Death Discov. 2023 Jul 27;9(1):263 (IF=7.109, 2区）

（12）Weihao Wang, Fang Kou, Juan Wang, Zhigang Quan, Shuting Zhao, Yifei Wang, Xin Hu, Hunan Sun* (co-correspondence) and Longkui Cao*. Pretreatment with millet-derived selenylated soluble dietary fiber ameliorates dextran sulfate sodium-induced colitis in mice by regulating inflammation and maintaining gut microbiota balance. Front. Nutr., 07 September 2022. doi.org/10.3389/fnut.2022.928601 (IF=6.59，1区)

（13）Xie DP, Gong YX, Lee J, Jeong EM, Ren CX, Guo XY, Han YH, Cui YD, Lee SJ, Kwon T, Sun HN*. Peroxiredoxin 5 protects HepG2 cells from ethyl β-carboline-3-carboxylate-induced cell death via ROS-dependent MAPK signalling pathways. J Cancer 2022 Sep 6;13(11):3258-3267. (IF=4.47，3区)

（14） ChenXi Ren1†, Xin Jin2†, DanPing Xie1 , XiaoYu Guo1 , LiYun Yu1 , YuDong Cui1*, Taeho Kwon3* and HuNan Sun1,* Hispidin attenuates bleomycin-induced idiopathic pulmonary fbrosis via an anti-oxidative efect in A549 cells. Appl Biol Chem (2021) 64:74 (IF=3.206，4区)

（15）Jin MH, Chen DQ, Jin YH, Han YH, Sun HN(co-correspondence), Kwon T. Hispidin inhibits LPS-induced nitric oxide production in BV-2 microglial cells via ROS-dependent MAPK signaling. Exp Ther Med. 2021 Sep;22(3):970. I(F=2.751，4区)

（16）Lee J, Gong YX, Xie DP, Jeong H, Seo H, Kim J, Park YH, Sun HN(co-correspondence), Kwon T. Anticancer Effect of ERM210 on Liver Cancer Cells Through ROS/Mitochondria-dependent Apoptosis Signaling Pathways. In Vivo. 2021 Sep-Oct;35(5):2599-2608. （IF=2.155，4区）

（17）Liang WF, Gong YX, Li HF, Sun FL, Li WL, Chen DQ, Xie DP, Ren CX, Guo XY, Wang ZY, Kwon T, Sun HN. Curcumin Activates ROS Signaling to Promote Pyroptosis in Hepatocellular Carcinoma HepG2 Cells. In Vivo. 2021 Jan-Feb;35(1):249-257. （IF=2.155，4区）

（18）Chandimali N, Koh H, Kim J, Lee J, Park YH, Sun HN (co-correspondence), Kwon T. BRM270 targets cancer stem cells and augments chemo-sensitivity in cancer.Oncol Lett. 2020 Oct;20(4):103 (IF=2.3，4区)

（19）Han YH, Zhang YQ, Jin MH, Jin YH, Qiu MY, Li WL, He C, Yu LY, Hyun JW, Lee J, Yoon DY, Sun HN (co-correspondence), Kwon T.Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway. Biochem Biophys Res Commun. 2020 Aug 27;529(3):635-641.（IF=3.322， 3区）

（20）Han YH, Li WL, Jin MH, Jin YH, Zhang YQ, Kong LZ, Yu LY, Hyun JW, Kwon J, Sun HN (co-correspondence), Kwon T. Peroxiredoxin II Inhibits Alcohol-induced Apoptosis in L02 Hepatocytes Through AKT/β-Catenin Signaling Pathway. Anticancer Res. 2020 Aug;40(8):4491-4504 (IF=1.8，4区)

（21）Gong YX, Liu Y, Jin YH, Jin MH, Han YH, Li J, Shen GN, Xie DP, Ren CX, Yu LY, Lee DS, Kim JS, Jo YJ, Kwon J, Lee J, Park YH, Kwon T, Cui YD, Sun HN* Picrasma quassioides Extract Elevates the Cervical Cancer Cell Apoptosis Through ROS-Mitochondrial Axis Activated p38 MAPK Signaling Pathway. In Vivo. 2020 Jul-Aug;34(4):1823-1833（IF=1.6，4区）

（22）Xie DP, Gong YX, Jin YH, Ren CX, Liu Y, Han YH, Jin MH, Zhu D, Pan QZ, Yu LY, Lee DS, Lee J, Kim J, Park YH, Hyun JW, Kwon T, Cui YD, Sun HN*.Anti-tumor Properties of Picrasma quassioides Extracts in H-Ras G12V Liver Cancer Are Mediated Through ROS-dependent Mitochondrial Dysfunction. Anticancer Res. 2020 Jul;40(7):3819-3830 (IF=1.8，4区)

（23）Han YH, Jin MH, Jin YH, Yu NN, Liu J, Zhang YQ, Cui YD, Wang AG, Lee DS, Kim SU, Kim JS, Kwon T, Sun HN*. Deletion of Peroxiredoxin II Inhibits the Growth of Mouse Primary Mesenchymal Stem Cells Through Induction of the G0/G1 Cell-cycle Arrest and Activation of AKT/GSK3β/β-Catenin Signaling. In Vivo. 2020 Jan-Feb;34(1):133-141. (IF=1.6，4区)

（24）YingHao Han†, DongQin Chen†, MeiHua Jin†, YingHua Jin , Jing Li, GuiNan Shen , WeiLong Li, YiXi Gong, YingYing Mao, DanPing Xie, DongSeok Lee, LiYun Yu, SunUk Kim, JiSu Kim ,Taeho Kwon* , YuDong Cui*and HuNan Sun* Anti-infammatory efect of hispidin on LPS induced macrophage infammation through MAPK and JAK1/STAT3 signaling pathways. Appl Biol Chem (2020) 63:21 (IF=1.6，4区)

（25）肖婉秋，张惠娜，任晨曦，郭晓宇，李楠，丛杰，冯耀元，孙虎男（*）过量表达peroixredoxin V 抑制苦木提取物诱导的宫颈癌SiHa细胞凋亡，中国细胞生物学学报，2023,45（01）：35-43

专著

《过氧化物酶与细胞》，东北林业大学出版社，ISBN：978-7-5674-2188-2，第一作者， 2020.07。

（3）发明专利